The portrait (puzzle) of a Williams Honors Scholar and engineer

“The joke in my family is that I put together a puzzle of the United States when I was about 18 months old,” says Amanda Jancewicz, a chemical engineering major at The University of Akron (UA) who for the past four and a half years has been assembling a far greater and more intricate puzzle: the self-portrait of a Williams Honors Scholar and engineer.

The first piece of that portrait fell into place when, as a junior at Padua Franciscan High School in Parma, Ohio, Jancewicz visited UA and its Drs. Gary B. and Pamela S. Williams Honors College (WHC) and immediately felt at home.

“I thought it was great to be at a larger state school with all the amenities, but it didn’t feel large when I was here — it felt like I was in a smaller community, with people who genuinely wanted me to be here,” says Jancewicz, who was accepted into the WHC and received its most prestigious award, the Lisle M. Buckingham/Owen O. and Della M. Orr Honors Scholarship.

Amanda Jancewicz, chemical engineering major on The University of Akron campus

Amanda Jancewicz

In fact, she felt so at home that she called the College of Engineering to see if she could begin doing research the summer before her first year. Judit Puskas, former professor of engineering at UA, invited her to join a research group studying “acid-catalyzed methacrylation of polyisoprene,” otherwise known as “novel UV-curable rubbers,” a method of using UV light to cross-link polymer chains for electronic coating applications.

Jancewicz would later present the results of that research in her Honors Research Project, a major project required of all Williams Honors Scholars, and in a poster presentation given during her sophomore year at the 2016 International Elastomer Conference in Pittsburgh, Pa., for which she won the “Best Undergraduate Poster Award.”

At the conclusion of that first summer of research, Jancewicz moved into the Honors Complex and joined the Honors Emerging Leaders Program, which she describes as a “springboard” for social involvement and networking at the University.

“A few hours after move-in, we started socializing with all of the other Emerging Leaders across three residence halls, and the next week consisted of many ice-breaker activities, leadership speakers, and meeting a ton of new people, which pushed me out of my comfort zone immediately,” she says. “I’m a naturally introverted person, and meeting all those people helped my confidence to blossom. … By sophomore year, I felt much more comfortable talking about myself during co-op interviews.”

Her identity was forming — the pieces coming together to reveal a bright and budding engineer. Through the College of Engineering’s co-op program, Jancewicz would go on to complete five co-op rotations with The Lubrizol Corp., a specialty chemicals provider in Wickliffe, Ohio, working in various roles to help produce materials used in everyday products ranging from shampoo and laundry detergent to shoes, medical devices, CPVC piping, and coatings for gym floors.

Her performance was rewarded with a full-time job offer. After graduating next spring, Jancewicz will begin working as a project engineer for Lubrizol Advanced Materials, responsible for the scope, design, budgeting and implementation of capital projects throughout Lubrizol sites globally.

“What is cool about this position, and about being a project engineer in general, is that I will be working to put all of the pieces together to create a finished, cohesive system to serve other engineers and technical groups in the company, whether in manufacturing, process development, R&D, safety systems, or site services,” she says. “I’m amazed at how all the complex units work together to make materials that consumers use in a multitude of products, every single day. You’re impacting the masses in a much different way than, say, a doctor would for an individual patient — you’re impacting so many people at once.”

Jancewicz adds that her engineering education has been reinforced — like a portrait framed, firmly mounted and secured — by her extensive leadership experiences at UA. She has been an Honors Delegate, responsible for interacting with visiting students, parents and dignitaries. She is the national vice president and initiation director for the Tau Beta Pi engineering honor society. She is a member of the College of Engineering’s Dean’s Team and Women in Engineering, and an engineering tutor and learning assistant. She is a current leadership advisor, and former president, of the Engineering Service Design Team, which recently created an adaptable canoe seat for the Akron Rotary Camp for Children with Special Needs. She has been a UA class representative for the American Society of Chemical Engineers and for the Engineering Student Council. She has also participated in community service projects through the UA student organizations RooCatholic and serveAkron.

With these and other finishing touches — such as her completion of the Akron Marathon in 2018, her participation in intramural sports and avid support for the Zips men’s soccer team — the portrait of Amanda Jancewicz, Williams Honors Scholar and engineer, is complete, a masterpiece in blue and gold.

“It boils down to the fact that there are so many opportunities available to Honors and engineering students at the University,” she says. “There are so many student groups and design teams to join, and we all feel like one big family because we are interconnected through our involvement, majors and study groups.”

As interconnected, one might say, as the pieces of a puzzle.

COLLEGE OF ENGINEERING

In our College of Engineering, you can choose from five areas of study and contribute to teams that build race cars, rockets, and biomedical devices that improve life.

Williams Honors College

Honors ComplexStudents in our prestigious Williams Honors College live in the Honors Residence Hall with other high-achieving, self-motivated students. They can apply for additional scholarships, and gain leadership experience through student organizations and through the Honors Leadership Summit. Further, students in the Williams Honors College design their own research focus, and get personal attention from faculty advisers.

Dr. Hossein Tavana, Professor and Biomedical Engineering Department Chair

Dr. Hossein Tavana, Professor and Biomedical Engineering Department Chair

With Federal $2.3M grant, University of Akron professor and students are contributing to novel breast cancer treatment and research

Breast cancer treatment and research have made great strides since the late 1800s when the first radical mastectomy, or breast removal surgery, was performed by American surgeon William Halsted as a new way to treat that type of cancer. Lots has improved since then with less extensive surgeries and radiation treatment, but there’s still work to be done against the disease that is diagnosed in about 288,000 women and 2,700 men in the U.S. each year.

Contributions to cancer research

At The University of Akron (UA), a top public urban research institution, Dr. Hossein Tavana, professor and chair of the Department of Biomedical Engineering, is collaborating with a research team at the University of Michigan to understand how breast cancer cells that metastasize to bone survive for many years before being “triggered” to grow, and what fuels their growth to form metastatic tumors. The results could provide greater insight into how to prevent the lethal recurrence of the disease, thus lowering the mortality from breast cancer. The research is being funded by a $2.3 million grant from the U.S. Department of Defense that was awarded in summer 2022.

The contributions to cancer research that Tavana and his Tissue Engineering Microtechnologies research group make is to create tissue engineered models of breast tumors to help understand disease mechanisms, improve drug testing, and discover more effective anticancer drugs.

This time, for a project that only began a few months ago, they’re trying to understand the specific mechanisms that keep breast cancer cells dormant in bone and what helps them grow. It could be a process similar to stem cells, where stem cells remain dormant and start growing when they receive a signal that they’re needed to work in the body and regenerate or repair a tissue.

Tavana Research Group

From left to right, the Tavana Research Group members: Davonn Henderson, Astha Lamichhane, Hannah Combs, Jacob Heiss, Hossein Tavana, Anju Rana Magar, Pouria Rafsanjani Nejad, and Prasiddha Guragain.

Transforming clinical care

A common type of breast cancer is called hormonal receptor-positive breast cancer. The receptors on the cancer cells "catch" estrogen to help them grow and develop tumors. "In this subtype of breast cancer, the cells typically metastasize to bone, and there are effective therapies designed and available to this subtype of patients," said Tavana. "Often, there’s no sign of disease for many years. But then, at some point, in later stages of life, patients come back with tumors in their bones."

These cells metastasize early in the disease process and enter the bone marrow and stay there dormant for years until something activates them to begin growing. Current hormone therapies for patients with estrogen receptor-positive breast cancer cannot prevent the breast cancer cells from growing in bone and turning fatal.

"About 75% of all breast cancers are identified as hormone receptor-positive, meaning that cancer cells overproduce a receptor to increase the intake of a hormone and fuel their growth," said Tavana. "We think that the impact on metastasized bone marrow breast cancer is huge because if you can come up with mechanisms that are targetable by therapeutics, then you can increase the life span of the patient.

"Through our research, we expect to identify novel treatment strategies to eliminate estrogen receptor-positive breast cancer cells from bone. These mechanisms will point to new therapy opportunities to eventually transform clinical care by eliminating cancer cells from bone and preventing recurrent, metastatic disease."

Tissue Engineering Microtechnologies

In addition to studying cancer, Tavana’s research interests also include biofluid mechanics of lungs and tissue engineering from stem cells. He manages the Tissue Engineering Microtechnologies lab in UA’s College of Engineering and Polymer Science. There, Tavana and his students develop novel tissue engineered models, such as human tumor models to study cancer drug resistance, generate neural cells from stem cells for cell replacement therapies of neurodegenerative disorders, and develop lung airway models to study therapeutics delivery to lungs. Projects in the lab have been funded by the National Institutes of Health, the National Science Foundation, and Department of Defense.

As one of the leading causes of mortality around the world, cancer occurrences will increase as the human population grows, but through investment and research, more and more effective treatments become available. “As a scientist I like challenging questions that are difficult to tackle,” said Tavana. “The challenging nature of cancer research provides a great opportunity for scientific studies that will hopefully lead to curing patients.”

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Story by Alex Knisely.

Media contact: Cristine Boyd, 330-972-6476 or cboyd@uakron.edu.